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NOT YET RECRUITING
NCT07823192
PHASE2

A Randomized Controlled Trial Evaluating the Efficacy of Soaking Endotracheal Tube in Dexamethasone Solution for Prevention of Postoperative Sore Throat After Laparoscopic Cholecystectomy

Sponsor: KRL Hospital, Islamabad

View on ClinicalTrials.gov

Summary

The goal of this clinical trial is to learn if topical application of dexamethasone will prevent sore throat caused by endotracheal intubation in healthy patients undergoing elective surgery. The main question it aims to answer is: • Does soaking the endotracheal tube in steroid solution before intubation lower the incidence of postoperative sore throat? Researcher will compare dexamethasone-soaked endotracheal tube to placebo (normal saline-soaked endotracheal tube) to see if topical steroid application in this way reduces development of sore throat. Participants will be: * Intubated with an endotracheal tube, that was either soaked in normal saline or dexamethasone solution, at induction of general anesthesia prior to undergoing elective cholecystectomy * Interviewed by the researcher 24 hours after their surgery to assess if they experienced any throat soreness

Official title: Topical Dexamethasone Tube Soaking for Prevention of Postoperative Sore Throat (POST) Following Endotracheal Intubation for Laparoscopic Cholecystectomy: A Randomized Controlled Trial

Key Details

Gender

All

Age Range

18 Years - 65 Years

Study Type

INTERVENTIONAL

Enrollment

64

Start Date

2026-11

Completion Date

2027-03

Last Updated

2026-09-16

Healthy Volunteers

No

Interventions

DRUG

Steroid Drug

Endotracheal tube will be soaked in dexamethasone solution for 10 minutes prior to intubation

DRUG

Normal (0.9%) saline

Endotracheal tube will be soaked in normal saline for 10 minutes prior to intubation

Locations (1)

KRL Hospital Islamabad

Islamabad, Pakistan