Clinical Research Directory
Browse clinical research sites, groups, and studies.
A Randomized Controlled Trial Evaluating the Efficacy of Soaking Endotracheal Tube in Dexamethasone Solution for Prevention of Postoperative Sore Throat After Laparoscopic Cholecystectomy
Sponsor: KRL Hospital, Islamabad
Summary
The goal of this clinical trial is to learn if topical application of dexamethasone will prevent sore throat caused by endotracheal intubation in healthy patients undergoing elective surgery. The main question it aims to answer is: • Does soaking the endotracheal tube in steroid solution before intubation lower the incidence of postoperative sore throat? Researcher will compare dexamethasone-soaked endotracheal tube to placebo (normal saline-soaked endotracheal tube) to see if topical steroid application in this way reduces development of sore throat. Participants will be: * Intubated with an endotracheal tube, that was either soaked in normal saline or dexamethasone solution, at induction of general anesthesia prior to undergoing elective cholecystectomy * Interviewed by the researcher 24 hours after their surgery to assess if they experienced any throat soreness
Official title: Topical Dexamethasone Tube Soaking for Prevention of Postoperative Sore Throat (POST) Following Endotracheal Intubation for Laparoscopic Cholecystectomy: A Randomized Controlled Trial
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
64
Start Date
2026-11
Completion Date
2027-03
Last Updated
2026-09-16
Healthy Volunteers
No
Conditions
Interventions
Steroid Drug
Endotracheal tube will be soaked in dexamethasone solution for 10 minutes prior to intubation
Normal (0.9%) saline
Endotracheal tube will be soaked in normal saline for 10 minutes prior to intubation
Locations (1)
KRL Hospital Islamabad
Islamabad, Pakistan