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NOT YET RECRUITING
NCT07823777
NA

Appendectomy as an Adjunct Procedure in Endometriosis Surgery

Sponsor: Mount Sinai Hospital, Canada

View on ClinicalTrials.gov

Summary

This study addresses a common but unresolved clinical decision in endometriosis surgery: whether to perform an adjunct appendectomy. Currently, this decision is often based on individual surgeon judgement or institutional practice rather than robust evidence. This randomized controlled study aims to determine if removing a normal appearing appendix at the time of endometriosis surgery impacts post-operative recurrence of pelvic pain and endometriotic lesions at 12 months. Secondary outcomes include pathology of the appendix and complication rate of the procedure. Participants will be randomized to appendectomy or no appendectomy at the time of their planned endometriosis surgery. The study also includes an observational cohort that participants may opt to join if they do not wish to be randomized. Data are expected to guide surgical decision-making and contribute to the development of standardized surgical guidelines.

Official title: Appendectomy as an Adjunct Procedure in Endometriosis Surgery (AppEND)

Key Details

Gender

FEMALE

Age Range

18 Years - 50 Years

Study Type

INTERVENTIONAL

Enrollment

240

Start Date

2027-04

Completion Date

2029-04

Last Updated

2026-09-16

Healthy Volunteers

No

Conditions

Interventions

PROCEDURE

Appendectomy

Removal of the appendix at the time of endometriosis surgery

PROCEDURE

Standard of Care (SOC)

If the appendix appears normal during surgery it will not be removed