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Demedetomidine and Remifentanil in Electroconvulsive Therapy (ECT)
Sponsor: Inonu University
Summary
Electroconvulsive therapy (ECT) is a treatment modality that induces therapeutic seizures through electrical stimulation for the management of certain psychiatric disorders. Nearly all ECT procedures are performed under general anesthesia. However, ECT is commonly associated with acute hyperdynamic responses immediately following electrical stimulation, including transient hypertension and tachycardia. These acute hemodynamic changes may pose significant risks, particularly in patients with ischemic heart disease, hypertension, or cerebrovascular disease. Therefore, the hemodynamic response, seizure quality, and recovery profile are critical factors influencing the choice of anesthetic and adjuvant agents. The primary goal of anesthesia for ECT is to maintain hemodynamic stability without compromising seizure duration or quality while ensuring rapid and safe recovery
Official title: Comparison of Three Different Anesthetic Methods in ECT
Key Details
Gender
All
Age Range
18 Years - 60 Years
Study Type
INTERVENTIONAL
Enrollment
24
Start Date
2026-09-21
Completion Date
2027-04-15
Last Updated
2026-09-29
Healthy Volunteers
No
Conditions
Interventions
Saline (0.9% NaCl)
Saline will infused over 10 minutes (total volume: 30 mL)
Dexmedetomidine
Dexmedetomidine at a dose of 0.5 μg/kg will infused over 10 minutes (total volume: 30 mL)
Remifentanil
Remifentanil at a dose of 1 μg/kg will infused over 10 minutes (total 30 ml)
Locations (1)
Inonu Universitesi Turgut Ozal Tıp Merkezi
Malatya, Battalgazi, Turkey (Türkiye)