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RECRUITING
NCT07824817
PHASE4

Demedetomidine and Remifentanil in Electroconvulsive Therapy (ECT)

Sponsor: Inonu University

View on ClinicalTrials.gov

Summary

Electroconvulsive therapy (ECT) is a treatment modality that induces therapeutic seizures through electrical stimulation for the management of certain psychiatric disorders. Nearly all ECT procedures are performed under general anesthesia. However, ECT is commonly associated with acute hyperdynamic responses immediately following electrical stimulation, including transient hypertension and tachycardia. These acute hemodynamic changes may pose significant risks, particularly in patients with ischemic heart disease, hypertension, or cerebrovascular disease. Therefore, the hemodynamic response, seizure quality, and recovery profile are critical factors influencing the choice of anesthetic and adjuvant agents. The primary goal of anesthesia for ECT is to maintain hemodynamic stability without compromising seizure duration or quality while ensuring rapid and safe recovery

Official title: Comparison of Three Different Anesthetic Methods in ECT

Key Details

Gender

All

Age Range

18 Years - 60 Years

Study Type

INTERVENTIONAL

Enrollment

24

Start Date

2026-09-21

Completion Date

2027-04-15

Last Updated

2026-09-29

Healthy Volunteers

No

Interventions

DRUG

Saline (0.9% NaCl)

Saline will infused over 10 minutes (total volume: 30 mL)

DRUG

Dexmedetomidine

Dexmedetomidine at a dose of 0.5 μg/kg will infused over 10 minutes (total volume: 30 mL)

DRUG

Remifentanil

Remifentanil at a dose of 1 μg/kg will infused over 10 minutes (total 30 ml)

Locations (1)

Inonu Universitesi Turgut Ozal Tıp Merkezi

Malatya, Battalgazi, Turkey (Türkiye)