Clinical Research Directory

The Role Oral Microbiome in the Development and Progression of Aorta Aneurysm and Carotid Atherosclerosis

Sponsor: Semmelweis University

Summary

The goal of this observational study is to compare the microbiome (bacterial al community) of the diseased vascular site and the oral cavity with specific attention to chronic inflammatory periodontitis in patients who have aorta aneurysm or carotid stenosis needing surgical treatment. The main question it aims to answer is whether pathogen members of the oral microbial community, that cause periodontal disease, are also present in the diseased vascular site proving its translocation from the oral cavity to the vascular system. We hypothesize that bacteria causing chronic periodontal disease can be found at the diseased vascular site highlighting the importance of maintaining and restoring oral health as preventive measure for vascular diseases. Participants will be asked to take part in a dental screening before vascular surgery, during which few samples will be taken non-invasively for analysis.

Official title: The Role Oral Microbiome in the Development and Progression of Vascular Diseases

Key Details

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Locations (1)