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Ketamine Treatment for Treatment-Resistant Depression - the Role of Framing
Sponsor: Valdemar Landgren
Summary
Ketamine is a medicine used in psychiatry for treatment-resistant depression. This study compares two ways of framing ketamine treatment: a psychedelic framing and a biomedical framing. The study will examine whether the framing affects depressive symptoms, treatment experience, tolerability, and longer-term outcomes.
Official title: A Single-center Open-label Randomized Parallel-group Superiority Trial to Compare the Efficacy of Psychedelic and Biomedical Framing of Intravenous Ketamine for Treatment-resistant Depression - the KetSet Trial
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
120
Start Date
2026-09
Completion Date
2030-08
Last Updated
2026-09-17
Healthy Volunteers
No
Conditions
Interventions
Psychedelic framing
The intervention includes: * Psychedelic framed patient information (video) * Psychedelic environment during infusions (mindfulness practice, music, eye mask) and psychological support provided towards engaging in the inner experience * Interview on the ketamine-induced experience
Biomedical framing
The intervention includes: * Biomedically framed patient information (video) * Psychological support provided during the infuion towards alleviating side effects such as dissociation * CADSS and BPRS
Locations (1)
Brain Stimulation Clinic, Skaraborg's Hospital
Skövde, Västra Götaland County, Sweden