Clinical Research Directory
Browse clinical research sites, groups, and studies.
Evaluation of the Aloe Vera Anti-inflammatory Effect on Apical Periodontitis.
Sponsor: Ain Shams University
Summary
The goal of this clinical trial is to evaluation aloe vera as intracanal medication anti-inflammatory also inter-appointment pain incidence compared with calcium hydroxide. The main questions it aims to answer are: Does aloe vera reduced pro-inflammatory cytokine (IL-1b)? Researchers will compare aloe vera to calcium hydroxide intra-canal medication to see if it works to modulate the inflammatory response in necrotic teeth with apical periodontitis. Participants will: Receive the intra-canal medications following root canal preparation for 14 days, periapical tissue fluid samples will be collected after access cavity preparation and 14days post medication placement. Pre-operative pain level and 24h, 48h post medication placement will be recorded.
Official title: Evaluation of the Aloe Vera Anti-inflammatory Effect on Apical Periodontitis, Randomized Clinical Trial; In Vivo Study
Key Details
Gender
All
Age Range
18 Years - 60 Years
Study Type
INTERVENTIONAL
Enrollment
33
Start Date
2024-08-05
Completion Date
2026-02-17
Last Updated
2026-09-17
Healthy Volunteers
No
Conditions
Interventions
Aloe vera gel
aloe vera gel concentration is (100% w/v).
Calcium Hydroxide (Ca(OH)2) Intracanal Medication
\<30% wt
Locations (1)
Faculty of dentistry, Ain shams university
Cairo, Abbasia, Egypt