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Comparative Evaluation of Omega-3 and Resveratrol Supplementation in Periodontitis Patients
Sponsor: Izmir Katip Celebi University
Summary
This retrospective comparative study aims to evaluate the effects of resveratrol and omega-3 supplementation as adjuncts to non-surgical periodontal treatment on clinical periodontal parameters in patients with periodontitis. A total of 60 systemically healthy, non-smoking patients will be evaluated and categorized into three groups according to their recorded supplementation status: a resveratrol group receiving non-surgical periodontal treatment plus resveratrol supplementation (n=20), an omega-3 group receiving non-surgical periodontal treatment plus omega-3 supplementation (n=20), and a non-supplemented control group receiving non-surgical periodontal treatment alone (n=20). Periodontal outcomes will be assessed at baseline and at 1 and 3 months after non-surgical periodontal treatment using probing pocket depth, clinical attachment level, plaque index, gingival index, and bleeding on probing. The study aims to compare the clinical periodontal outcomes of the three groups and determine whether adjunctive resveratrol or omega-3 supplementation is associated with additional clinical benefits beyond non-surgical periodontal treatment alone.
Official title: A Retrospective Comparative Evaluation of the Effects of Adjunctive Omega-3 and Resveratrol Supplementation to Non-Surgical Periodontal Therapy on Clinical Periodontal Parameters in Systemically Healthy Patients With Periodontitis.
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
OBSERVATIONAL
Enrollment
60
Start Date
2025-01-01
Completion Date
2028-03-15
Last Updated
2026-09-18
Healthy Volunteers
No
Conditions
Interventions
trans-resveratrol
Trans-resveratrol supplementation at a dose of 250 mg twice daily (500 mg/day total) during non-surgical periodontal treatment.
Omega-3 (EPA+DHA)
Omega-3 fatty acid supplementation at a total daily dose of 1320 mg, including 640 mg EPA and 480 mg DHA, during non-surgical periodontal treatment.
No supplementation
Patients who underwent non-surgical periodontal treatment without receiving resveratrol or omega-3 fatty acid supplementation during the treatment period
Locations (1)
İzmir Katip Çelebi University, Faculty of Dentistry
Izmir, İzmir, Turkey (Türkiye)