Clinical Research Directory

Inclusion Criteria: * Male or female, aged 40-75 years； * Diagnosed with COPD; * Post-bronchodilator FEV1/FVC \<0.7 * Emphysematous lesions demonstrated by HRCT; * Hemoglobin-corrected DLCO%predicted ≥20% and \<70%; * Post-bronchodilator FEV1%predicted ≤80%; * COPD Assessment Test (CAT) score ≥3; Exclusion Criteria: * History of ≥2 COPD exacerbations leading to hospitalization within 1 year prior to screening, or a COPD exacerbation leading to hospitalization within 2 months prior to screening; * Current or previous history of malignancy; * An assessed life expectancy of \<1 year; * Respiratory tract infection or systemic infection requiring treatment, or severe localized infection within 4 weeks prior to screening; * History of invasive or non-invasive mechanical ventilation within 4 weeks prior to screening; * Diagnosis of pneumonia within 3 months prior to screening; * Abnormal coagulation function affecting the safety of fiberoptic bronchoscopy procedures at screening; * Subjects requiring long-term maintenance anticoagulant therapy or antiplatelet therapy, who are unable to discontinue such medications for at least 1 week prior to cell collection and cell infusion;