Clinical Research Directory

Inclusion Criteria: * Age \>50 years * Persistent knee pain \>4 weeks (In the case of patients presenting with bilateral knee pain, the knee with more severe symptoms was selected for study purposes.) * Patient must have undergone conservative treatment for at least 4 weeks. * Radiologically diagnosed as knee osteoarthritis with Kellgren-Lawrence grading scale, grades 2 and 3 * Primary osteoarthritis of the knee Exclusion Criteria: * Immunosuppressed patients (Examples: uncontrolled diabetes, HIV, under corticosteroid medication, etc.) * History of surgery around the knee joint * History of significant knee injury * Patients diagnosed with connective tissue disorders, inflammatory disorders of joints, congenital anomalies of the lower extremity, tumors, and metabolic diseases of bone * Patients who had received intra-articular steroid injections within the past 6 months * Patient who has not attempted conservative treatment. * Presence or suspected of infection or ulceration at the injection site. * Patients with a platelet count less than 1.5 lakhs/microliters * Congenital anomalies of the lower extremity * Patients on NSAIDs 2 days before and 2 days after PRP injection. * Patients with coexisting backache, hip pain * Pregnant or lactating females. * Cases where the diagnosis is uncertain. * Patients not willing to participate in the study