Clinical Research Directory
Browse clinical research sites, groups, and studies.
FueL Use During eXercise in Males and Females
Sponsor: University of Toronto
Summary
This study will investigate whether pre-exercise nutrition influences sex differences in fuel utilization during endurance exercise. Twenty-four recreationally active adults (12 females and 12 males) will complete three experimental exercise trials in a randomized, counterbalanced crossover design. Before each trial, participants will consume either a carbohydrate beverage, a protein-based beverage, or a flavour-matched non-caloric beverage representing the fasted condition. Thirty minutes later, participants will complete 90 minutes of moderate-intensity cycling followed by a cycling time-to-task-failure test. Whole-body carbohydrate and fat oxidation, exogenous substrate oxidation, blood metabolites, and exercise performance will be assessed.
Official title: Influence of Pre-exercise Nutrition on Exercise Fuel Use in Males and Females
Key Details
Gender
All
Age Range
18 Years - 35 Years
Study Type
INTERVENTIONAL
Enrollment
24
Start Date
2026-09-30
Completion Date
2027-06-30
Last Updated
2026-09-18
Healthy Volunteers
Yes
Conditions
Interventions
Pre-exercise carbohydrate beverage
A carbohydrate beverage providing 1 g glucose/kg body mass, enriched with 1 mg/kg body mass \[U-13C6\]-D-glucose for assessment of exogenous carbohydrate oxidation, with calorie-free flavouring. The beverage will be consumed within 5 minutes, 30 minutes before exercise.
Pre-exercise protein beverage
A protein-based beverage providing 0.45 g protein/kg body mass and supplemented with 0.24 g fat/kg body mass to match the energy content of the carbohydrate condition. The beverage is enriched with L-\[1-13C\]leucine and flavour-matched to the carbohydrate beverage. It will be consumed within 5 minutes, 30 minutes before exercise.
Fasted control beverage
A non-caloric beverage consisting of water and sugar-free flavouring, flavour-matched to the carbohydrate beverage. The beverage will be consumed within 5 minutes following an overnight fast, 30 minutes before exercise.
Locations (1)
Goldring Centre for High Performance Sport
Toronto, Ontario, Canada