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Short-Term Effects of Low-FODMAP, NICE Dietary Advice, and Intermittent Fasting in Irritable Bowel Syndrome
Sponsor: Acibadem University
Summary
The goal of this clinical trial is to compare the short-term effects of three dietary approaches in adults with irritable bowel syndrome (IBS): a low-FODMAP diet, adapted National Institute for Health and Care Excellence (NICE) dietary advice, and adapted NICE dietary advice combined with 16:8 intermittent fasting. The main questions this study aims to answer are: How do these three dietary approaches affect IBS symptom severity after two weeks? How do these three dietary approaches affect IBS-related quality of life after two weeks? The researchers hypothesize that the low-FODMAP diet will produce the greatest short-term reduction in IBS symptom severity. The study will also explore whether adding 16:8 intermittent fasting to adapted NICE dietary advice provides additional benefit. Researchers will compare the three dietary groups to determine whether the changes in IBS symptoms and quality of life differ between the dietary approaches. Participants will: Follow one of the three dietary approaches for two weeks. Attend study visits at the beginning of the study, after one week, and after two weeks. Keep records of their food and fluid intake. Complete questionnaires about IBS symptoms, quality of life, anxiety, and depression. Record their stool form and frequency during the study.
Official title: Short-Term Effects of a Low-FODMAP Diet, Adapted NICE Dietary Advice, and Adapted NICE Dietary Advice Combined With Intermittent Fasting on Symptoms and Quality of Life in Irritable Bowel Syndrome: A Three-Arm, Non-Randomized Controlled Dietary Intervention Study
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
90
Start Date
2024-02-01
Completion Date
2024-11-01
Last Updated
2026-09-21
Healthy Volunteers
No
Conditions
Interventions
Low-FODMAP Diet
Participants followed a researcher-designed low-FODMAP elimination diet for two weeks. The dietary intervention was delivered by a dietitian who had completed Monash University Low-FODMAP Diet Training. Foods containing fermentable oligosaccharides, lactose, excess fructose, and polyols were restricted. The reintroduction phase of the low-FODMAP diet was not implemented during the two-week study period.
Adapted NICE Dietary Advice
Participants followed adapted NICE dietary advice for two weeks. The recommendations included eating regular meals and avoiding prolonged fasting, drinking at least 2 liters of water per day, limiting
16:8 Intermittent Fasting
Participants followed a 16:8 intermittent fasting regimen in addition to adapted NICE dietary advice for two weeks. All meals were consumed within an 8-hour eating window, either from 11:00 to 19:00 or from 12:00 to 20:00, followed by a 16-hour fasting period. One or two snacks were permitted within the eating window. No specific restriction on fiber or FODMAP intake was applied.
Locations (1)
Acibadem Kozyatagi Hospital
Istanbul, Turkey (Türkiye)