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Serum Adropin as an Indicator of Endothelial Dysfunction and Disease Severity in Obstructive Sleep Apnea in Obese Patients
Sponsor: Aswan University
Summary
1\. Objectives (Aim): To evaluate the role of serum adropin as a potential biomarker of endothelial dysfunction in OSA 1. Compare serum adropin levels between Obese patients with and without OSA. 2. Correlate serum adropin with OSA severity indices including the Apnea-Hypopnea Index (AHI) and Oxygen Desaturation Index (ODI) and cardiovascular complications. 3. Assess the relationship between serum adropin and endothelial dysfunction markers (endothelin-1). 4. Evaluate adropin's predictive ability for endothelial impairment among OSA patients.
Key Details
Gender
All
Age Range
20 Years - 75 Years
Study Type
OBSERVATIONAL
Enrollment
80
Start Date
2026-09-15
Completion Date
2027-10-01
Last Updated
2026-09-21
Healthy Volunteers
Yes
Conditions
Interventions
Adropin
Fasting blood samples of Adropin were obtained by venipuncture in the morning following the sleep study.