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Effect of Tranexamic Acid-Modified Leukocyte- and Platelet-Rich Fibrin on Hemostasis and Wound Healing After Tooth Extraction in Patients Receiving Direct Oral Anticoagulants: A Randomized Split-Mouth Clinical Study
Sponsor: Cumhuriyet University
Summary
This randomized split-mouth clinical study evaluated the effects of tranexamic acid-modified leukocyte- and platelet-rich fibrin (L-PRF) on hemostasis, postoperative pain, and soft-tissue wound healing after tooth extraction in patients receiving direct oral anticoagulants (DOACs). In each participant, extraction sites were allocated to either tranexamic acid-modified L-PRF or an absorbable gelatin sponge as a local hemostatic intervention. Hemostasis was assessed 30 minutes after extraction, postoperative pain was evaluated at 24, 48, and 72 hours, and soft-tissue wound healing was assessed on days 7, 14, and 21.
Official title: Evaluation of the Effects of Local Application of Tranexamic Acid Combined With Leukocyte- and Platelet-Rich Fibrin on Hemostasis and Wound Healing After Tooth Extraction in Patients Receiving Direct Oral Anticoagulants
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
21
Start Date
2025-08-01
Completion Date
2026-01-05
Last Updated
2026-09-21
Healthy Volunteers
No
Interventions
Tranexamic Acid-Modified L-PRF
Participants received tranexamic acid-modified leukocyte- and platelet-rich fibrin (L-PRF) in the randomly allocated extraction socket. L-PRF was prepared from 8 mL of venous blood with the addition of 0.4 mL tranexamic acid (250 mg/5 mL) before centrifugation at 2700 rpm for 12 minutes. The resulting TXA-modified L-PRF was placed into the extraction socket as a local hemostatic intervention.
Absorbable Gelatin Sponge
Participants received an absorbable gelatin sponge in the randomly allocated extraction socket as a local hemostatic intervention.
Locations (1)
Sivas Cumhuriyet University Faculty of Dentistry
Sivas, Sivas, Turkey (Türkiye)