Clinical Research Directory

Inclusion Criteria: * Age 18-65 * Fluent in English * Approved for and scheduled to undergo acute amputation or revision amputation surgery (e.g. above-knee amputation with sciatic nerve ablation) OR sciatic nerve ablation for clinical indications (e.g. persistent pain, symptomatic neuroma, soft tissue breakdown, muscle atrophy, socket-related discomfort). * Willing and able to initiate participation within 14 days of surgery * Willing to perform at home studies * Possess adequate cognitive and communication abilities to describe their sensorimotor recovery during follow-up assessments * Demonstrate appropriate motivation and reliability to comply with scheduled training and evaluation sessions throughout the postoperative period * Able to travel to BWH/BWFH and Harvard University for all required visits without lodging support Exclusion Criteria: * • Passive or active metal implants incompatible with EMG * Pacemakers, deep brain stimulators, or other electronic implantables * Pregnancy or breastfeeding * Current seizure disorder or other neurologically limiting conditions * Cognitive or developmental disorders that limit task comprehension * Vascular disorders impeding regeneration * Known impairments in wound healing, including connective tissue disorders or under chronic systemic corticosteroid therapy * Extensive peripheral neuropathies that may hinder neural regeneration and functional RPNI development * Active smoker * Are unable to provide informed consent * Have a demonstrated history of poor protocol adherence * Pregnant at the time of screening