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Clinical and Hemodynamic Correlates of Different Polarities of HD-tDCS in COPD
Sponsor: Federal University of Paraíba
Summary
The aim of this pilot randomized clinical trial is to identify the acute effects of HD-tDCS in the diaphragm cortex on cerebral hemodynamics in individuals with COPD. The main questions to answer are: Is there a change in cortical metabolism (HbO and OXYHb consumption) during and immediately after the application of HD-tDCS? Are there any particularities in cortical hemodynamics between the different HD-tDCS polarities? Participants will perform three HD-tDCS sessions, each one with a different type of stimulation (anodal, cathodal and sham) lasting for 20 minutes. Before, during and after stimulation, near-infrared spectrography will be used as assessment instruments.
Official title: Clinical and Hemodynamic Correlates of Different Polarities of High-definition Transcranial Direct Current Stimulation in Chronic Respiratory Disease
Key Details
Gender
All
Age Range
18 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
20
Start Date
2023-10-05
Completion Date
2024-04-30
Last Updated
2026-09-21
Healthy Volunteers
No
Conditions
Interventions
High-definition Transcranial Direct Current Stimulation
Participants will receive stimulation through electrode positioning according to the International 10-20 System. The central electrode will be placed over the left diaphragm cortex, accompanied by four return electrodes. The current will be administered using a 3mA protocol for 20 minutes, with a 30-second ramp-up at the beginning and a 30-second ramp-down at the end of the stimulation for active groups. For the placebo group, the setup will remain identical; however, regarding the protocol, the device initially reaches a current of 3 mA and then drops to 0.1 mA within the first 30 seconds, remaining at this current for 20 minutes. A current of 3 mA will be reinstated only in the final 30 seconds, once again accompanied by ramp-up and ramp-down phases.
Sham High-definition Transcranial Direct Current Stimulation
Participants received sham stimulation using the same electrode positioning as the active conditions (International 10-20 System), with a central electrode over the left diaphragm cortex and four return electrodes. The device initially reached a current of 3 mA and then dropped to 0.1 mA within the first 30 seconds, remaining at this current for 20 minutes. A current of 3 mA was reinstated only in the final 30 seconds, accompanied by ramp-up and ramp-down phases, replicating the initial and final sensations of active stimulation without delivering a sustained therapeutic current.
Locations (1)
Aging and Neuroscience Studies Laboratory
João Pessoa, Brazil