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Comparison of Wound Healing Duration Between Vacuum-Assisted Closure (VAC) and Conventional Dressings
Sponsor: Jinnah Postgraduate Medical Centre
Summary
This randomized controlled trial will compare vacuum-assisted closure (VAC) therapy with conventional wound dressings for the treatment of open contaminated and dirty wounds. The study will be conducted in the Department of General Surgery, Jinnah Postgraduate Medical Centre (JPMC), Karachi. Eligible patients aged 15 to 60 years with open contaminated or dirty wounds measuring 5-10 cm and classified as American Society of Anesthesiologists (ASA) grade I or II will be randomly allocated to either VAC therapy or conventional dressings. The primary outcome will be mean duration of wound healing, measured in days from initiation of the assigned treatment until complete wound healing according to predefined clinical criteria. The study will compare the duration of wound healing between the two treatment groups.
Official title: Comparison of Mean Duration of Wound Healing Between Vacuum-Assisted Closure (VAC) and Conventional Dressings for the Treatment of Wounds in Patients
Key Details
Gender
All
Age Range
15 Years - 60 Years
Study Type
INTERVENTIONAL
Enrollment
60
Start Date
2026-09-20
Completion Date
2026-12-09
Last Updated
2026-09-21
Healthy Volunteers
No
Conditions
Interventions
Vacuum-Assisted Closure (VAC) Therapy Description:
The wound will be covered with polyurethane foam and a multi-hole drain will be placed over it. The dressing will be sealed with an airtight dressing and connected to a negative-pressure system providing intermittent negative pressure of 125 mmHg, with 45 minutes ON and 15 minutes OFF cycles. VAC dressing changes will be performed every 48-72 hours.
Conventional Wound Dressing
Saline-soaked dressing will be placed over the wound and bandage applied, with dressing changes every 24 hours
Locations (1)
Jinnah Postgraduate Medical Centre
Karachi, Sindh, Pakistan