Clinical Research Directory

Inclusion Criteria: * Participants enrolled in the source studies who were aged 40 to 84 years at enrollment. * Availability of genetic data and plasma proteomic data for population-specific protein prediction modeling. * Participants with or without type 2 diabetes, depending on the source dataset and analytic objective. Exclusion Criteria: * Participants younger than 40 years or older than 84 years at enrollment in the source studies. * Participants lacking genetic data or plasma proteomic data required for protein prediction modeling. This study will conduct a retrospective secondary analysis of existing, controlled-access datasets. No new participants will be recruited or contacted. Type 2 diabetes genome-wide association summary statistics will also be used for association analyses; the participant-level eligibility criteria above apply to individual-level source-study records used for protein prediction modeling.