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CAIX-targeted PET/CT in Solid Tumors
Sponsor: Zhongnan Hospital
Summary
Tumor hypoxic microenvironment plays an important role in the initiation and progression of solid tumors, as well as tumor invasion, metastasis, and treatment resistance. Carbonic anhydrase IX (CAIX), as a crucial downstream molecule regulated by hypoxia-inducible factor-1 (HIF-1), is highly expressed in various solid tumors and is closely associated with tumor invasiveness, treatment response, and prognosis; thus, it represents an ideal target for tumor diagnosis and therapy. This study aims to explore the diagnostic value of CAIX-targeted PET/CT imaging in various solid tumors, as well as the correlation between tumor uptake and tissue CAIX expression.
Official title: Carbonic Anhydrase IX-targeted PET/CT Imaging for Detecting Solid Tumors
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
100
Start Date
2026-09-21
Completion Date
2031-12-31
Last Updated
2026-10-13
Healthy Volunteers
Yes
Interventions
68Ga-CAIX
The subjects receive a PET/CT scan 30-60 minutes after intravenous administration of 68Ga-CAIX
Locations (1)
Zhongnan hospital of Wuhan University
Wuhan, Hubei, China