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Incretin Therapy and Exercise in Type 2 Diabetes
Sponsor: University of Regina
Summary
This study will examine changes in brain and physical health in adults with type 2 diabetes who are initiating incretin-mimetic therapy (e.g., Ozempic, Mounjaro), and determine whether adding structured exercise provides additional benefits. Participants will be randomized to receive incretin-mimetic therapy alone or incretin-mimetic therapy plus a structured exercise program for 24 weeks. If the participant is randomly assigned to the incretin-based therapy alone group, they will have the opportunity to complete the same structured exercise program after the 24-week study period is complete. Brain health will be assessed through cognitive performance, mental health, and brain-mediated appetite regulation. The study will also assess gut microbiota and motor-cortex neuroplasticity as potential factors associated with changes in brain health, as well as glucose regulation, body composition, physical function, and cardiorespiratory fitness. Assessments will be completed at baseline, 8 weeks, and 24 weeks. Findings will help determine how incretin-mimetic therapy and exercise can be integrated to support brain and physical health in adults with type 2 diabetes.
Official title: Effects of Incretin Memetics and Exercise on Gut-brain and Metabolic Health in Persons With Type 2 Diabetes
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
110
Start Date
2026-09
Completion Date
2028-12
Last Updated
2026-09-22
Healthy Volunteers
No
Conditions
Interventions
Structured Exercise Program
A 24-week individualized exercise program consisting of three exercise sessions per week. The program will include resistance and aerobic exercise based on Canadian physical activity guidelines, with exercise selection and intensity adjusted to individual abilities and fitness levels. Two sessions per week will be supervised at the University of Regina and one session per week will be completed independently. Each session will last approximately 60-90 minutes. Participants will also receive guidance on adequate protein intake.
Locations (1)
Centre for Kinesiology
Regina, Saskatchewan, Canada