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Comparison of Capnography and Blood Gas PaCO₂ Measurements
Sponsor: Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Summary
Capnography provides continuous, non-invasive assessment of ventilation by measuring end-tidal carbon dioxide (EtCO₂). Different capnographic technologies, including mainstream, sidestream, and microstream capnography, may produce different EtCO₂ measurements depending on their sampling and measurement techniques. This prospective, non-randomized observational study was designed to compare EtCO₂ values obtained using mainstream, sidestream, and microstream capnography with carbon dioxide partial pressure (PCO₂) values obtained from clinically indicated blood gas analysis in adult patients presenting to the emergency department. For each participant, EtCO₂ measurements were obtained using the three capnographic methods in close temporal proximity to blood gas sampling. The relationship and agreement between blood gas PCO₂ and EtCO₂ measurements were planned to be evaluated using correlation analyses and Bland-Altman analysis. Additional analyses were planned according to whether the blood gas sample was arterial or venous.
Official title: Correlation of End-Tidal Carbon Dioxide Values Measured by Different Capnographic Devices With Blood Gas Analysis in Patients Presenting to Emergency Department: A Prospective Non-Randomized Study
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
135
Start Date
2024-05-01
Completion Date
2024-07-01
Last Updated
2026-09-22
Healthy Volunteers
Yes
Interventions
Mainstream Capnography
End-tidal carbon dioxide (etCO2) was measured using mainstream capnography. Participants were asked to breathe through an endotracheal tube connected to the capnography sensor, and monitoring was continued for at least six breaths to obtain a stable measurement. The mainstream etCO2 value was recorded simultaneously or in close temporal proximity to clinically indicated blood gas sampling and was compared with the PCO2 value obtained from the blood gas analysis.
Sidestream Capnography
End-tidal carbon dioxide (etCO2) was measured using sidestream capnography. A nasal cannula connected to the capnography monitor was placed in the participant's nostrils, and exhaled carbon dioxide was sampled during spontaneous breathing. The sidestream etCO2 value was recorded simultaneously or in close temporal proximity to clinically indicated blood gas sampling and was compared with the PCO2 value obtained from the blood gas analysis.
Microstream Capnography
End-tidal carbon dioxide (etCO2) was measured using microstream capnography. A nasal cannula connected to the capnography monitor was placed in the participant's nostrils, and exhaled carbon dioxide was sampled during spontaneous breathing. The microstream etCO2 value was recorded simultaneously or in close temporal proximity to clinically indicated blood gas sampling and was compared with the PCO2 value obtained from the blood gas analysis.
Locations (1)
University of Health Sciences, Sultan II. Abdülhamid Han Training and Research Hospital
Istanbul, Istanbul, Turkey (Türkiye)