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NCT07834944

ROSA-B: ALAN Exposure and Brain Health in Midlife Women With VMS

Sponsor: Beth Israel Deaconess Medical Center

View on ClinicalTrials.gov

Summary

This randomized, parallel-group study will examine how artificial light exposure during nighttime awakenings affects sleep and brain health in midlife women experiencing vasomotor symptoms, such as hot flashes and night sweats. Participants will be randomly assigned to exposure to either typical indoor-intensity light (approximately 100 lux) or dim light (less than 3 lux) during the night. The study will assess the effects of nighttime light exposure on sleep fragmentation, daytime alertness and sleepiness, stress responses, cognitive and emotional functioning, and daily functioning. It will also explore whether sleep fragmentation helps explain the effects of nighttime light exposure on stress and neuropsychological health. The findings may inform strategies to reduce nighttime light exposure and improve sleep and brain health in women during and after the menopause transition.

Official title: ROSA-B: Impact of Artificial Light at Night on Brain Health in Midlife Women With Vasomotor Symptom

Key Details

Gender

FEMALE

Age Range

45 Years - 58 Years

Study Type

INTERVENTIONAL

Enrollment

Start Date

2026-11-01

Completion Date

2030-11-01

Last Updated

2026-09-22

Healthy Volunteers

Yes

Conditions

Women in the Menopausal Period

Interventions

BEHAVIORAL

Artificial Light at Night (ALAN) 100 lux

Participants will be exposed to a controlled artificial-light-at-night condition during the scheduled overnight sleep episode. Light will be delivered using a standardized light source at a predetermined intensity and timing to examine its effects on sleep, brain health, and related physiological outcomes in midlife women with vasomotor symptoms.