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A-PRF AND HA AFTER IMPACTED THIRD MOLAR SURGERY
Sponsor: Inonu University
Summary
This randomized controlled clinical trial evaluated the effects of advanced platelet-rich fibrin (A-PRF) and hyaluronic acid (HA) on healing after surgical removal of impacted mandibular third molars. Participants were assigned to one of three groups: A-PRF applied to the extraction socket, HA applied to the extraction socket, or a control group receiving no additional biomaterial. Postoperative pain, facial swelling, and maximum mouth opening were assessed during the first postoperative week. Radiographic bone healing was evaluated using fractal dimension and mean gray value measurements on panoramic radiographs obtained on postoperative days 7 and 90. The study aimed to determine whether A-PRF or HA could improve postoperative clinical recovery and radiographic bone healing compared with standard treatment alone.
Official title: Effects of Advanced Platelet-Rich Fibrin and Hyaluronic Acid on Radiographic and Clinical Healing Following Impacted Mandibular Third Molar Surgery: A Randomized Controlled Clinical Trial
Key Details
Gender
All
Age Range
19 Years - 29 Years
Study Type
INTERVENTIONAL
Enrollment
47
Start Date
2025-08-11
Completion Date
2026-06-30
Last Updated
2026-09-29
Healthy Volunteers
Yes
Conditions
Interventions
Advanced Platelet-Rich Fibrin
Advanced platelet-rich fibrin (A-PRF) was prepared from autologous venous blood by centrifugation at 1500 rpm for 14 minutes. The resulting A-PRF membrane was placed into the extraction socket immediately after surgical removal of the impacted mandibular third molar.
Sodium hyaluronate
One milliliter of 0.8% sodium hyaluronate gel was applied directly into the extraction socket immediately after surgical removal of the impacted mandibular third molar.
Locations (1)
Inonu University Faculty of Dentistry
Malatya, Battalgazi, Turkey (Türkiye)