Clinical Research Directory

Inclusion Criteria: For part 1 and 2: must have given written informed consent (signed and dated) and any authorizations required by local law and be able to comply with all study requirements Only for part 1: For ATTR-CA participants: 1. males or females: age 18-90 years 2. with a confirmed diagnosis of ATTR-CA by standard criteria For AL-CA participants: 1. males or females: age 18-80 years 2. with a confirmed diagnosis of AL-CA by standard criteria For healthy participants: 1. males or females: age 18-80 years 2. no cardiac-related diseases Only for part 2: 1. males or females: age 18-90 years 2. suspected or confirmed ATTR-CA Exclusion Criteria: For part 1 and 2: 1. pregnancy or breastfeeding 2. severe claustrophobia 3. inability or refusal of consent 4. any condition deemed by the investigator to interfere with study results or increase participant risk Only for part 1: For ATTR-CA participants: 1. non-ischemic cardiomyopathy due to other causes of myocardial hypertrophy 2. diagnosis of primary or secondary AL-CA 3. contraindications for MRI (eGFR\<30ml/min/1.73m2; gadolinium allergy; metallic implants or device not suited for MRI) For AL-CA participants: co-diagnosis of multiple myeloma, Waldenström macroglobulinemia, or other lymphoproliferative disorders For healthy participants: any cardiac-related diseases based on medical history and corresponding clinical evaluations, including electrocardiography, echocardiography, and laboratory tests Only for part 2: 1. non-ischemic cardiomyopathy due to other causes of myocardial hypertrophy 2. contraindications for MRI (eGFR\<30ml/min/1.73m2; gadolinium allergy; metallic implants or device not suited for MRI)