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Effects of Nattokinase Supplementation on Strength Recovery and Muscle Damage Biomarkers Following Exercise-Induced Muscle Injury: A Pilot Study
Sponsor: National Taiwan Sport University
Summary
This pilot study aims to investigate whether 4 weeks of nattokinase supplementation (2,000 FU/day) affects recovery following exercise-induced muscle damage in healthy adult men. Approximately 12 to 16 participants aged 18 to 40 years will receive either nattokinase or a matching placebo during the supplementation period. After supplementation, participants will complete an exercise protocol designed to induce temporary muscle damage. Recovery will be evaluated using measures of muscle strength and exercise performance, muscle soreness, blood lactate, muscle oxygenation, and blood biomarkers related to muscle damage, inflammation, and oxidative stress. Measurements will be performed before and after the exercise-induced muscle damage protocol, including follow-up assessments during the recovery period. The study is intended to provide preliminary information on the potential effects of nattokinase supplementation on muscle recovery after strenuous exercise.
Key Details
Gender
MALE
Age Range
18 Years - 40 Years
Study Type
INTERVENTIONAL
Enrollment
14
Start Date
2026-09-03
Completion Date
2026-10-08
Last Updated
2026-09-23
Healthy Volunteers
Yes
Conditions
Interventions
Nattokinase
Participants will consume one capsule of nattokinase orally once daily, providing 2,000 FU/day, for 28 days.
Placebo
Participants will consume one matching placebo capsule orally once daily for 28 days. The placebo is matched in appearance and flavor to the nattokinase supplement.
Locations (1)
Graduate Institute of Sports Science, National Taiwan Sport University
Taoyuan, Taiwan, Taiwan