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Clinical and Radiographic Success of Modified LSTR Techniques in Primary Second Molars
Sponsor: Uşak University
Summary
This study aimed to evaluate and compare the clinical and radiographic success of different antibiotic and vehicle modifications of the Lesion Sterilization and Tissue Repair (LSTR) technique in infected mandibular primary second molars. The study included systemically healthy children aged 4-11 years. Participants were assigned to four treatment groups according to the antibiotic combination (3Mix or 2Mix) and vehicle used \[Macrogol-Propylene Glycol (MP) or normal saline (NS)\]: 3Mix-MP, 3Mix-NS, 2Mix-MP, and 2Mix-NS. Clinical outcomes were evaluated at 3, 6, and 12 months after treatment, and radiographic outcomes were evaluated at 6 and 12 months. The clinical and radiographic success of the four LSTR modifications was compared over the 12-month follow-up period.
Official title: EVALUATION OF THE CLINICAL AND RADIOGRAPHIC SUCCESS OF VARIOUS MODIFICATIONS OF THE LESION STERILIZATION AND TISSUE REPAIR TECHNIQUE IN PRIMARY SECOND MOLAR TEETH
Key Details
Gender
All
Age Range
4 Years - 11 Years
Study Type
INTERVENTIONAL
Enrollment
64
Start Date
2024-11-26
Completion Date
2026-03-05
Last Updated
2026-09-23
Healthy Volunteers
No
Conditions
Interventions
3Mix-MP Antibiotic Paste
The 3Mix antibiotic powder consisted of metronidazole, ciprofloxacin, and clindamycin mixed in a 1:1:1 ratio. Macrogol and propylene glycol were mixed in a 1:1 ratio to prepare the vehicle. Immediately before application, the antibiotic powder and the vehicle were combined at a 7:1 ratio to form a homogeneous paste, which was used as part of the LSTR treatment.
3Mix-NS Antibiotic Paste
The 3Mix antibiotic powder consisted of metronidazole, ciprofloxacin, and clindamycin mixed in a 1:1:1 ratio. Normal saline (NS) was used as the vehicle. Immediately before application, the antibiotic powder and normal saline were combined at a 7:1 ratio to form a homogeneous paste, which was used as part of the LSTR treatment.
2Mix-MP Antibiotic Paste
The 2Mix antibiotic powder consisted of metronidazole and ciprofloxacin mixed in a 1:1 ratio. Macrogol and propylene glycol were mixed in a 1:1 ratio to prepare the vehicle. Immediately before application, the antibiotic powder and the vehicle were combined at a 7:1 ratio to form a homogeneous paste, which was used as part of the LSTR treatment.
2Mix-NS Antibiotic Paste
The 2Mix antibiotic powder consisted of metronidazole and ciprofloxacin mixed in a 1:1 ratio. Normal saline (NS) was used as the vehicle. Immediately before application, the antibiotic powder and normal saline were combined at a 7:1 ratio to form a homogeneous paste, which was used as part of the LSTR treatment.
Locations (1)
Uşak University Faculty of Dentistry
Uşak, Uşak, Turkey (Türkiye)