Clinical Research Directory

Inclusion Criteria: * Child or adult of any age with congenital heart disease; enrollment of minors requires parent or legal-representative permission and assent when applicable. * Congenital heart disease with advanced cardiac and/or respiratory failure, associated pulmonary hypertension, or another protocol-defined trigger for specialized advanced-therapy evaluation. * Identification within an activated TORCH network cluster with an operational route to at least one authorized advanced-therapy or transplant center. * Ability to complete protocol-defined follow-up directly or through an authorized network pathway. * Provision of informed consent by the participant or legally authorized representative, and assent when applicable, according to local requirements. Exclusion Criteria: * Absence of congenital heart disease as the underlying condition defining the advanced cardiac and/or respiratory-failure pathway. * No authorized route for protocol evaluation or follow-up at the time of enrollment. * Unable or unwilling to provide informed consent or legally authorized permission when required. * The prespecified multidisciplinary evaluation and advanced-pathway decision were already completed and remain clinically current before enrollment.