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Fractional CO2 Laser vs Dermabrasion With 5-Fluorouracil for Acquired Leukoderma
Sponsor: Al-Azhar University
Summary
This randomized controlled prospective single-blinded comparative clinical study aims to compare the efficacy and safety of fractional carbon dioxide (CO2) laser therapy versus mechanical dermabrasion, both combined with topical 5-fluorouracil, in the treatment of acquired non-vitiligo leukoderma. The study will evaluate repigmentation, clinical improvement, patient satisfaction, and treatment-related adverse effects.
Official title: Fractional Co2 Laser vs Dermabrasion 5-Flurouracil Delivery in Acquired Leukoderma: A Comparative Study
Key Details
Gender
All
Age Range
18 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
16
Start Date
2026-08-26
Completion Date
2027-08-26
Last Updated
2026-09-24
Healthy Volunteers
No
Conditions
Interventions
Fractional CO2 Laser
Fractional carbon dioxide (CO2) laser therapy followed by topical 5-fluorouracil application. Laser parameters will be adjusted according to lesion size and site.
Dermabrasion
Mechanical dermabrasion using manual or motor-driven dermabrasion followed immediately by topical 5-fluorouracil application.
5-Fluorouracil
Topical 5-fluorouracil applied immediately after fractional CO2 laser or dermabrasion according to the assigned study arm.
Locations (1)
Faculty of medicine, Al-Azhar University Assuit
Asyut, Asyut Governorate, Egypt