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Detection of Biomarkers for Prosthetic Infection Type - (DEBIT)
Sponsor: Portsmouth Hospitals NHS Trust
Summary
Prosthetic joint infection (PJI) is a significant cause of failure in hip and knee arthroplasty and is often difficult to diagnose using current methods. This study aims to identify novel biomarkers for early and accurate diagnosis of PJI using nanopore sequencing technology (Oxford Nanopore Technologies). By analysing microbial profiles and host immune responses in samples from patients undergoing revision surgery, the study will compare infected and non-infected cases. Biomarkers will be investigated in periprosthetic tissue as well as less invasive sample types, including synovial fluid and blood, with the goal of improving early diagnosis and guiding future treatment strategies.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
40
Start Date
2026-02-13
Completion Date
2027-11-30
Last Updated
2026-09-24
Healthy Volunteers
No
Conditions
Interventions
Prosthetic joint replacement
Primary joint replacement
Locations (2)
Queen Alexandra Hospital
Portsmouth, United Kingdom
Southampton General Hospital
Southampton, United Kingdom