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Positron Emission Tomography (PET) Imaging of Chemotherapy-Induced Cardiotoxicity
Sponsor: Washington University School of Medicine
Summary
This study is a single center, phase 1 clinical imaging study designed to assess the role of 68Ga-Galmydar Positron Emission Tomography (PET) imaging for detection of cardiotoxicity in human subjects with breast cancer or lymphoma undergoing treatment with anthracycline for cancer therapy.
Official title: PET Imaging of Chemotherapy-Induced Cardiotoxicity
Key Details
Gender
All
Age Range
21 Years - 99 Years
Study Type
INTERVENTIONAL
Enrollment
36
Start Date
2026-11-01
Completion Date
2029-12-12
Last Updated
2026-09-24
Healthy Volunteers
No
Interventions
68Ga-Galmydar
68Ga-Galmydar is a positron-emitting radioisotope used prior to PET/MRI imaging. Prior to imaging, patients will receive one single intravenous administration of 2.5 mCi ± 20% (2.0-3.0 mCi) of 68Ga-Galmydar followed by a 10 mL normal saline flush on Imaging Day -1.
PET/MRI
Patients will undergo PET/MRI according to standard of care imaging.
18F-FDG
18F-FDG is administered by an intravenous injection of 10 mCi ± 20% (8-12 mCi) followed by a 10 mL normal saline flush.
Locations (1)
Washington University School of Medicine
St Louis, Missouri, United States