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NOT YET RECRUITING
NCT07838649
PHASE1

Positron Emission Tomography (PET) Imaging of Chemotherapy-Induced Cardiotoxicity

Sponsor: Washington University School of Medicine

View on ClinicalTrials.gov

Summary

This study is a single center, phase 1 clinical imaging study designed to assess the role of 68Ga-Galmydar Positron Emission Tomography (PET) imaging for detection of cardiotoxicity in human subjects with breast cancer or lymphoma undergoing treatment with anthracycline for cancer therapy.

Official title: PET Imaging of Chemotherapy-Induced Cardiotoxicity

Key Details

Gender

All

Age Range

21 Years - 99 Years

Study Type

INTERVENTIONAL

Enrollment

36

Start Date

2026-11-01

Completion Date

2029-12-12

Last Updated

2026-09-24

Healthy Volunteers

No

Interventions

DRUG

68Ga-Galmydar

68Ga-Galmydar is a positron-emitting radioisotope used prior to PET/MRI imaging. Prior to imaging, patients will receive one single intravenous administration of 2.5 mCi ± 20% (2.0-3.0 mCi) of 68Ga-Galmydar followed by a 10 mL normal saline flush on Imaging Day -1.

DEVICE

PET/MRI

Patients will undergo PET/MRI according to standard of care imaging.

DRUG

18F-FDG

18F-FDG is administered by an intravenous injection of 10 mCi ± 20% (8-12 mCi) followed by a 10 mL normal saline flush.

Locations (1)

Washington University School of Medicine

St Louis, Missouri, United States