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Nalbuphine With Remimazolam Versus Nalbuphine With Propofol for Knee Arthroscopy
Sponsor: Wuhan Fourth Hospital
Summary
This study compared two combinations of medicines used for sedation and pain relief in adults undergoing knee arthroscopy for knee joint injuries. One group received nalbuphine with remimazolam, and the other received nalbuphine with propofol. The study examined pain, sedation, cognitive function, and adverse events. A total of 100 adults aged 18 to 65 years were randomly assigned to the two groups, with 50 participants in each group. All participants underwent surgery under combined spinal-epidural anesthesia. Pain, sedation, and cognitive function were assessed immediately after surgery and at 6, 12, and 24 hours after surgery.
Official title: Investigating the Effect of Subanesthetic Doses of Nalbuphine Combined With Remimazolam in Patients Undergoing Arthroscopic Knee Surgery for Knee Joint Injuries
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
100
Start Date
2025-04-10
Completion Date
2025-10-02
Last Updated
2026-09-24
Healthy Volunteers
No
Conditions
Interventions
Nalbuphine
Nalbuphine 0.1 mg/kg was administered intravenously at induction in both study groups.
Remimazolam
Remimazolam 0.2-0.3 mg/kg was administered intravenously at induction in the experimental group. If body movement occurred during the procedure, an additional intravenous dose of 0.05 mg/kg was administered as needed until completion.
Propofol
Propofol 1.5-2.0 mg/kg was administered intravenously at induction in the active comparator group. If body movement occurred during the procedure, an additional intravenous dose of 0.5 mg/kg was administered as needed until completion.
Locations (1)
Wuhan Fourth Hospital
Wuhan, Hubei, China