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Brain Stimulation to Improvement After Cerebellar Damage
Sponsor: George Wittenberg
Summary
The work will examine the mechanisms and potential therapeutic effects of transcranial magnetic stimulation on upper-limb sensorimotor function in individuals with cerebellar dysfunction, including those with damage due to stroke or autoimmune disease. The study team will work toward a goal of non-invasive stimulation-based neuromodulatory interventions for cerebellar disorders using a closely integrated, clinically oriented cross-species approach. There will be a related study in nonhuman primates.
Official title: Neuromodulation of Cerebellar Circuitry
Key Details
Gender
All
Age Range
18 Years - 100 Years
Study Type
INTERVENTIONAL
Enrollment
60
Start Date
2026-12
Completion Date
2028-12
Last Updated
2026-09-24
Healthy Volunteers
Yes
Interventions
Transcranial Magnetic Stimulation
Stimulation of continuous theta burst stimulation at 80% of resting motor threshold over the region targeted for modulation after behavioral testing, with resting of behavior afterwards.
Locations (1)
University of Pittsburgh
Pittsburgh, Pennsylvania, United States