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NOT YET RECRUITING
NCT07839936
PHASE2

A Study of VERVE-102 (LY4636581) in Adults With or at High Risk for Cardiovascular Disease

Sponsor: Verve Therapeutics, Inc.

View on ClinicalTrials.gov

Summary

The purpose of this study is to measure the change in bad cholesterol (LDL-C) with VERVE-102 compared to placebo in adults who have plaque buildup in their arteries or are at high risk of developing it.

Official title: A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study of VERVE-102, a One-Time Dose Gene Editing Medicine, in Adults With or at High Risk for Atherosclerotic Cardiovascular Disease (ASCVD) Who Require Additional Low-Density Lipoprotein-Cholesterol (LDL-C) Lowering

Key Details

Gender

All

Age Range

18 Years - 70 Years

Study Type

INTERVENTIONAL

Enrollment

175

Start Date

2026-10

Completion Date

2030-03

Last Updated

2026-09-24

Healthy Volunteers

No

Interventions

DRUG

VERVE-102

Administered IV

DRUG

Placebo

Administered IV

Locations (1)

Epic Medical Research

DeSoto, Texas, United States