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Hemodynamic Evaluation and Fluid Response Observation Through Respiratory Maneuvers
Sponsor: University Hospital Pilsen
Summary
This study evaluates whether respiratory maneuvers can induce measurable hemodynamic changes and whether these changes may be used to assess fluid responsiveness in healthy volunteers. Hemodynamic parameters are continuously monitored non-invasively during four respiratory maneuvers, passive leg raising, and a fluid challenge. The hemodynamic responses to individual respiratory maneuvers are compared with the response to fluid administration.
Key Details
Gender
All
Age Range
18 Years - 100 Years
Study Type
INTERVENTIONAL
Enrollment
26
Start Date
2024-10-22
Completion Date
2025-12-08
Last Updated
2026-09-24
Healthy Volunteers
Yes
Conditions
Interventions
Respiratory Maneuvers and Fluid Responsiveness Assessment Protocol
Participants perform four respiratory maneuvers: maximal inspiration followed by breath-hold (M1), maximal expiration followed by breath-hold (M2), Valsalva maneuver (M3), and Müller maneuver (M4). Each respiratory maneuver lasts 20 seconds. The respiratory maneuvers are followed by passive leg raising and a fluid challenge consisting of 500 mL of balanced crystalloid administered intravenously over 10 minutes. Hemodynamic variables are continuously monitored non-invasively throughout the protocol.
Locations (1)
University Hospital Pilsen
Pilsen, Czech Republic, Czechia