Clinical Research Directory

COMT and IL6 Genotype-Phenotype Associations in Fibromyalgia and Myofascial Pain Syndrome

Sponsor: Istanbul Aydın University

Summary

Fibromyalgia (FM) and myofascial pain syndrome (MPS) are chronic pain conditions that may share some clinical features but differ in the distribution and extent of pain and associated symptoms. The biological factors contributing to these differences remain incompletely understood. This observational study aims to compare the distribution of two pain-related genetic variants, COMT rs4680 and IL6 rs1800795, between individuals with FM and MPS and to investigate their associations with clinical characteristics. Participants will undergo standardized clinical assessment, including measures of symptom burden, physical functioning, and energy/fatigue. In participants with MPS, musculoskeletal ultrasonography will be used as an adjunct to clinical examination to support phenotypic characterization. Genetic analysis will be performed using DNA obtained from peripheral venous blood. COMT rs4680 and IL6 rs1800795 will be genotyped using a TaqMan probe-based real-time polymerase chain reaction method. The study is intended to explore genotype-phenotype associations in two clinically characterized chronic pain conditions. The investigated genetic variants are not being evaluated as diagnostic tests, and no intervention is assigned as part of the study.

Official title: INTEGRATING ULTRASOUND-SUPPORTED PHENOTYPING WITH COMT RS4680 AND IL6 RS1800795 GENOTYPE-PHENOTYPE ASSOCIATIONS İN FIBROMYALGIA AND MYOFASCIAL PAIN SYNDROME

Key Details

Conditions

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