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Cardiorespiratory Fitness After Lobectomy Versus Sublobar Resection
Sponsor: Tongji Hospital
Summary
This observational study will compare changes in cardiorespiratory fitness after lobectomy and sublobar resection. Sublobar resection includes segmentectomy and wedge resection. Patients who can undergo pulmonary resection and meet the eligibility criteria will be studied during routine clinical care; the research will not assign the surgical procedure or add a study-specific intervention. Cardiopulmonary exercise testing (CPET) and pulmonary function testing will be performed before surgery and at routine follow-up visits 6 and 12 months after surgery. Changes from the preoperative assessment will be compared within each surgical group and between the two groups. The study will also examine the relationship between CPET measurements and postoperative complications.
Official title: Impact of Lobectomy Versus Sublobar Resection on Cardiorespiratory Fitness: An Observational Study Based on Cardiopulmonary Exercise Testing
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
604
Start Date
2022-08-01
Completion Date
2027-07-31
Last Updated
2026-09-25
Healthy Volunteers
No
Conditions
Interventions
Lobectomy
Anatomic resection of an entire pulmonary lobe. The procedure may be performed via open thoracotomy or minimally invasive approaches, including video-assisted thoracoscopic surgery (VATS) or robot-assisted thoracoscopic surgery (RATS). The surgical approach and technique are determined by the treating surgeon according to routine clinical practice, tumor characteristics, patient anatomy, and pulmonary function. No randomization or study-specific intervention is assigned by the research protocol.
Sublobar Resection
Lung-preserving resection including segmentectomy and wedge resection. Segmentectomy is an anatomic resection of one or more bronchopulmonary segments. Wedge resection is a non-anatomic resection of lung parenchyma containing the lesion, typically with a wedge-shaped margin. The procedure may be performed via open thoracotomy or minimally invasive approaches, including VATS or RATS. The specific surgical procedure and approach are determined by the treating surgeon according to routine clinical practice, tumor characteristics, patient anatomy, and pulmonary function. No randomization or study-specific intervention is assigned by the research protocol.
Locations (1)
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Wuhan, Hubei, China