Clinical Research Directory

Inclusion Criteria: * Confirmed diagnosis of Cystic Fibrosis according to CF Foundation guidelines (based on positive sweat chloride test and/or presence of disease-causing mutations in homozygous state or compound heterozygous state in CFTR gene). * Patients eligible for ETI therapy (having at least one F508del mutation or a mutation known to be responsive to ETI). * Age above 5 years old. Exclusion Criteria: * Known allergy or hypersensitivity to ETI or any of its components. * Moderate hepatic impairment (Child-Pugh Class B) or severe hepatic impairment (Child-Pugh Class C). * Presence of chronic inflammatory diseases unrelated to CF (e.g., Crohn's disease, glomerulonephritis, or thrombotic disorders) that could confound P2X7R levels.