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Exercise Intensity and Circulating CD34+ Progenitor Cell Mobilization in Trained Adults
Sponsor: Samarra University
Summary
This randomized crossover study investigated whether exercise intensity influences the mobilization of circulating CD34+ progenitor cells when total external work is matched. Forty trained male endurance athletes completed two cycling exercise conditions in randomized order: a higher-intensity condition at 70% of peak work rate (WRpeak) and a lower-intensity condition at 30% WRpeak. Both conditions were performed until 250 kJ of external work had been completed and were separated by a washout period of at least 7 days. Venous blood samples were obtained before exercise, immediately after exercise, and at 15, 30, and 60 minutes of recovery. The primary outcome was the absolute concentration of viable circulating CD34+ cells measured using single-platform flow cytometry. Secondary outcomes included CD34+CD45dim, CD34+CD133+, and CD34+VEGFR2+ cell phenotypes, together with adrenergic, metabolic, chemokine, growth-factor, and cardiovascular responses. The study was designed to determine whether exercise intensity produces distinct progenitor-cell mobilization responses despite identical external work.
Official title: Exercise Intensity Shapes Circulating CD34+ Progenitor-Cell Mobilization Despite Matched External Work: A Randomized Crossover Study
Key Details
Gender
MALE
Age Range
18 Years - 35 Years
Study Type
INTERVENTIONAL
Enrollment
40
Start Date
2026-08-03
Completion Date
2026-09-09
Last Updated
2026-09-25
Healthy Volunteers
Yes
Interventions
Higher-Intensity Work-Matched Cycling Exercise
Participants performed cycle-ergometer exercise at 70% of individual peak work rate (WRpeak) until a total external mechanical work of 250 kJ was completed. Venous blood samples were obtained before exercise, immediately after exercise, and at 15, 30, and 60 minutes of recovery.
Lower-Intensity Work-Matched Cycling Exercise
Participants performed cycle-ergometer exercise at 30% of individual peak work rate (WRpeak) until a total external mechanical work of 250 kJ was completed. Venous blood samples were obtained before exercise, immediately after exercise, and at 15, 30, and 60 minutes of recovery.
Locations (1)
College of Physical Education and Sports Sciences, University of Samarra
Samarra, Muhafazat Salah ad Din, Iraq