Clinical Research Directory

Exploring the Impact of Diurnal Variation on Coagulation Function in Patients Undering Tumor Surgery

Sponsor: Fudan University

Summary

Studies have shown that compared to the evening, the platelet adhension and aggregation functions of normal individuals are stronger in the morning, reaching peak at around 8AM or 9AM. Fibrinolysis is weakest at 7-11AM, and most active at midnight. previous studies have been contradictory regarding the rhythm of plasmin. Some show the level of plasmin complexes is highest at night, while some show higher in the morning and some show there is no rhythmicity. Since patients with tumors often have a hypercoagulable state, we try to find a method to assess whether cancer patients have the same circadian with heathy individuals. And whether the surgery time(in the morning or in the evening) will affect the tumor patients' postoperative coagulation function

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