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Long-acting Local Vaginal Cuff Anesthesia Following Hysterectomy
Sponsor: The University of Texas Health Science Center, Houston
Summary
The purpose of this study is to compare recovery unit and post operation day (POD) 1 pain score in women following elective robotic assisted TLH (RA-TLH) for benign indication with and without local vaginal cuff injection of short acting bupivacaine and long acting Exparel, to evaluate postoperative pain management and control by assessing the amount and frequency of NSAIDS and opioids taken and to assess bleeding, vaginal discharge and or vaginal dehiscence at the postoperative follow up visit.
Official title: Long-acting Local Vaginal Cuff Anesthesia Following Hysterectomy: LAVA Trial
Key Details
Gender
FEMALE
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
104
Start Date
2026-09-17
Completion Date
2028-09-15
Last Updated
2026-09-25
Healthy Volunteers
No
Conditions
Interventions
Combined Bupivacaine and Exparel
In addition to the Laparoscopic Transversus Abdominis Plane (TAP) Block, participants will receive 20 cc of a mixture of 40 cc of short term 0.25% bupivacaine hydrochloride and long term 20 mL of Exparel® (266 mg/20 mL) mixed with 100cc of normal saline (total amount 160 cc) to the vaginal cuff using William's cystoscopy needle. The mixture will be infiltrated evenly at the uterosacral ligament with care (10 cc on each uterosacral ligament) taken to distribute the injection across the full length of the cuff at the end of the procedure.
Normal Saline (NS)
In addition to the Laparoscopic Transversus Abdominis Plane (TAP) Block, participants will get will get vaginal cuff infiltration with 20 cc of injectable NS at the end of the procedure.
Locations (1)
The University of Texas Health Science Center, Houston
Houston, Texas, United States