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Helping Kentuckians Overcome Depression and Opioid Addiction With Brain Stimulation
Sponsor: University of Kentucky
Summary
This study will compare transcranial magnetic stimulation (TMS) with sham TMS in people with opioid use disorder who are taking buprenorphine and have major depressive disorder with ongoing depressive symptoms. The study will evaluate whether TMS improves depressive symptoms and reduces opioid craving. The study will also assess smoking behaviors, treatment acceptability, and any side effects related to TMS.
Key Details
Gender
All
Age Range
18 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
60
Start Date
2026-10-15
Completion Date
2028-12-31
Last Updated
2026-09-25
Healthy Volunteers
No
Interventions
Transcranial Magnetic Stimulation (TMS)
Intermittent theta burst stimulation (iTBS) delivered over the left dorsolateral prefrontal cortex using a TMS coil.
Sham Transcranial Magnetic Stimulation (TMS)
Sham Transcranial Magnetic Stimulation (TMS) delivered using the same procedure as active TMS without a significant electric field induced around the brain.
Locations (1)
University of Kentucky
Lexington, Kentucky, United States