Clinical Research Directory

Effect of a Brassicaceae-Enriched Diet on Menopausal Symptoms in Women With Breast Cancer Receiving Antiestrogen Therapy

Sponsor: Azienda Ospedaliero, Universitaria Pisana

Summary

This study aims to evaluate whether increasing the intake of Brassicaceae vegetables may help reduce menopausal symptoms in women with hormone-sensitive breast cancer who are receiving adjuvant antiestrogen therapy. Participants are randomly assigned to one of two groups. Women in the intervention group receive nutritional advice to include at least five servings per week of Brassicaceae vegetables, such as broccoli, cabbage, cauliflower, Brussels sprouts, radishes, mustard, or other vegetables from this family, in their usual diet. Women in the control group receive a standard nutritional assessment without specific advice to increase Brassicaceae intake. Clinical and nutritional assessments are performed at the beginning of the study and after 3 and 6 months. The main purpose is to compare vasomotor menopausal symptoms, particularly hot flashes and night sweats, between the two groups. The study also evaluates other menopausal symptoms, body measurements, blood pressure, and selected blood markers. After the 6-month assessment, participants are followed by telephone at 9, 12, and 18 months to evaluate long-term adherence to the nutritional advice, general health, and menopausal symptoms.

Official title: Evaluation of the Benefits of Brassicaceae on Menopausal Symptoms in Patients With a History of Breast Cancer Treated With Anti-estrogens.

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