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Exercise and Tissue-Specific Insulin Sensitivity in South Asian and Nordic Women With Previous Gestational Diabetes
Sponsor: Oslo University Hospital
Summary
South Asian women have a high risk of developing type 2 diabetes, and the risk is particularly high after gestational diabetes. This study examined whether eight weeks of supervised vigorous exercise improves insulin sensitivity in South Asian women with previous gestational diabetes, and whether the response differs from that of Nordic women with the same history. Participants trained four times per week, with two whole-body resistance sessions and two high-intensity interval cycling sessions. Before and after the intervention, insulin sensitivity was measured with an oral glucose tolerance test combined with stable-isotope tracers, and cardiorespiratory fitness, muscle strength and body composition were assessed. Blood, urine and tissue samples were collected for multi-omics analyses.
Official title: Effects of Physical Exercise on Glucose Metabolism and Related Metabolic Signatures in South Asian and Nordic Women With Previous Gestational Diabetes (DIASA-Ex)
Key Details
Gender
FEMALE
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
43
Start Date
2024-10-01
Completion Date
2026-09-01
Last Updated
2026-09-25
Healthy Volunteers
No
Conditions
Interventions
Exercise
Eight weeks of supervised training with four sessions per week: two whole-body resistance training sessions and two high-intensity interval cycling sessions, totalling approximately five hours of vigorous exercise per week. Resistance sessions comprised three lower-body and six upper-body exercises, 1-4 sets per exercise, progressing from 19 sets in the first sessions to 28 sets in the last sessions. Each set consisted of 12 repetitions during weeks 1-3 and 10 repetitions during weeks 4-8, with 1-4 repetitions in reserve. Interval sessions were performed on a cycle ergometer. One weekly session used 7-minute bouts at 82-87% of maximal heart rate with 3 minutes of rest between bouts, progressing from 3 to 5 bouts. The other weekly session used 2-minute bouts at an intensity reaching at least 90% of maximal heart rate during the final 30 seconds, with 2 minutes of rest between bouts, progressing from 6 to 9 bouts.
Locations (1)
Aker sykehus
Oslo, Norway