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PPI Dosing Per CYP2C19 Genotype
Sponsor: University of Florida
Summary
This study is being done to determine if the dosing of proton pump inhibitor (PPI) medication based on CYP2C19 genotype-derived phenotype leads to improved healing of erosive esophagitis compared to conventional PPI medication dosing.
Official title: A Pilot Study to Assess Healing of Erosive Esophagitis in Patients Randomized to Conventional PPI Doses Versus Dosing Based on CYP2C19 Genotype
Key Details
Gender
All
Age Range
18 Years - 90 Years
Study Type
INTERVENTIONAL
Enrollment
200
Start Date
2026-10
Completion Date
2028-04-01
Last Updated
2026-09-28
Healthy Volunteers
Yes
Interventions
CYP2C19 based dosing Proton Pump Inhibitors
Pantoprazole dosing based on CYP2C19 phenotypes
Conventional proton pump inhibitor dose
conventional PPI dose of Pantoprazole 40 mg once or twice daily