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Safety, Tolerability, PK, and PD of TGM-148 in Healthy Participants
Sponsor: Tangram Therapeutics Plc
Summary
The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamic (PD) effects of single ascending doses of TGM-148 in healthy adults
Official title: A First-in-human, Randomised, Double-masked (Sponsor Unmasked), Placebo-controlled, Parallel Group, Single Ascending Dose Trial to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of a Single Subcutaneous Dose of TGM-148 in Healthy Participants
Key Details
Gender
All
Age Range
18 Years - 45 Years
Study Type
INTERVENTIONAL
Enrollment
40
Start Date
2026-10
Completion Date
2028-03
Last Updated
2026-09-28
Healthy Volunteers
Yes
Conditions
Interventions
TGM-148
TGM-148 is an investigational medicinal product administered by subcutaneous injection according to a protocol-defined regimen.
Placebo
Placebo administered by subcutaneous injection according to a protocol-defined regimen.
Locations (1)
Hammersmith Medicines Research
London, United Kingdom