Clinical Research Directory

Inclusion Criteria: * Patients aged 18 years or older. * General health status compatible with dental treatment (ASA I-II). * Ability to understand the study, sign the informed consent form, and comply with the follow-up protocol. * Presence of one or more dental implants in function for at least 12 months, placed at any center, regardless of connection type or the presence of platform switching. * Screw-retained implant-supported prostheses (single-unit, partial, or complete). * Presence of at least one implant diagnosed with peri-implantitis, according to the criteria of the 2017 Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. Exclusion Criteria: * Refusal to participate in the study or inability to provide informed consent. * Non-acceptance of the proposed treatment. * Pregnancy or breastfeeding. * Treatment with drugs or presence of diseases that may alter the healing of peri-implant tissues or interfere with the response to treatment (e.g., immunosuppressants, systemic corticosteroids at immunosuppressive doses, or treatment with antiresorptive or antiangiogenic agents). * Implants restored with cemented prostheses. * Implants with mobility or with radiographic bone loss exceeding 50%. * Surgical or non-surgical peri-implant treatment of the affected implant within the previous 12 months. * Systemic antibiotic treatment within the previous 3 months.