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Smart Scaffolds, Stronger Smiles Smarter Healing: AI-Boosted Multiphasic Scaffold Design for PDL Regeneration
Sponsor: Misr University for Science and Technology
Summary
The periodontal ligament is vital for tooth support, and its loss, frequently resulting from periodontitis, trauma, or endodontic lesions, presents a significant clinical challenge; global cases of severe periodontitis increased by 91.54% from 1990 to 2021. Conventional monophasic scaffolds offer a uniform environment, limiting their efficacy in regenerating complex, multi-tissue structures like the periodontium. This study introduces an AI-enhanced, 3D multi-phasic scaffold to precisely restore the periodontal apparatus and overcome the limitations of non-uniform tissue growth seen in some multiphasic designs. The methodology involved sequential steps: high-resolution CBCT and intraoral scans to capture defect geometry; precise defect mapping to define the Target Regeneration Volume; and AI Mesh mixer implementation to generate three distinct, seamlessly graded lattice zones. This AI-driven design ensures Optimal Biomechanics (Precision) by perfectly matching the scaffold's stiffness to native tissue, thereby eliminating stress-shielding.
Official title: AI- Powered Multiphasic 3D Printed Scaffold for Periodontal Defect Regeneration
Key Details
Gender
All
Age Range
Any - Any
Study Type
INTERVENTIONAL
Enrollment
1
Start Date
2025-11-25
Completion Date
2028-09-03
Last Updated
2026-09-28
Healthy Volunteers
No
Interventions
AI algorithms generated a 3D multiphasic, graded lattice structure
Patients underwent minimally invasive surgical intervention. Following preoperative diagnosis of severe infrabony defects exhibiting mobility and loss of periodontal support, a minimally invasive flap was elevated, and the defect was thoroughly debrided and prepared. The custom-printed multiphasic scaffold was seated into the defect with precision to ensure stability, and complete primary flap closure was achieved \[
Locations (1)
Giza
Giza, Egypt