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INtubation With Sedation Only to Preserve Independent Respiratory Effort Trial
Sponsor: Vanderbilt University Medical Center
Summary
The INtubation with Sedation Only to Preserve Independent Respiratory Effort (INSPIRE) trial is a pragmatic, non-blinded, parallel-group, randomized clinical trial comparing the effect of intubation with sedation only (intervention group) versus intubation with sedation plus neuromuscular blockade (control group) among adults undergoing emergency tracheal intubation in the ED and ICU with regard to the outcomes of: (1) hypoxemia during intubation, (2) successful intubation on the first attempt, and (3) awake immobility and PTSD symptoms. Patients who are determined by treating clinicians to require emergency tracheal intubation and who meet eligibility criteria will be enrolled and randomly assigned to either intubation with sedation only or intubation with sedation plus neuromuscular blockade.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
228
Start Date
2026-09-28
Completion Date
2030-05-29
Last Updated
2026-09-30
Healthy Volunteers
No
Conditions
Interventions
Intubation with a sedative medication only
Patients in the sedation only group will undergo emergency tracheal intubation with sedation only (without receiving neuromuscular blockade) on the first attempt. The choice and dose of the sedative agent(s) (e.g., etomidate, ketamine, propofol, or other) will will be at the discretion of the operator and in accordance with usual clinical practice in the participating unit.
Intubation with a sedative medication and neuromuscular blockade agent
Patients in the sedation plus neuromuscular blockade group will receive sedation plus neuromuscular blockade prior to the first attempt at intubation. The choice and dose of the sedative agent(s)) (e.g., etomidate, ketamine, propofol, or other) and neuromuscular blockade agent(s) (e.g., succinylcholine, rocuronium, or other) will be at the discretion of the operator and in accordance with usual clinical practice in the participating unit.
Locations (1)
Vanderbilt University Medical Center
Nashville, Tennessee, United States