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A Study to Learn About Switching to a Monthly Study Medicine Called Berobenatide (PF-08653944) to Help Keep Weight Off in People With Overweight or Obesity
Sponsor: Pfizer
Summary
The purpose of this study is to learn about the safety and effectiveness of berobenatide in adults with overweight or obesity who have already lost weight while taking semaglutide or tirzepatide. The study does not include people with diabetes. Participants will be in the study for about 11 months.
Official title: A PHASE 3 STUDY TO EVALUATE THE SWITCH TO MONTHLY BEROBENATIDE FOR MAINTAINING WEIGHT IN ADULTS WHO ARE ON WEEKLY SEMAGLUTIDE OR TIRZEPATIDE (VESPER-SWITCH)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
660
Start Date
2026-09-30
Completion Date
2028-02-16
Last Updated
2026-10-15
Healthy Volunteers
No
Interventions
Semaglutide
Participants will receive Semaglutide administered subcutaneously.
Berobenatide
Participants will receive berobenatide solution for injection as subcutaneous injection.
Tirzepatide
Participants will receive Tirzepatide administered subcutaneously.
Locations (16)
University of Alabama at Birmingham
Birmingham, Alabama, United States
Velocity Clinical Research - Los Angeles
Los Angeles, California, United States
Southern California Clinical Research
Santa Ana, California, United States
Diablo Clinical Research, LLC dba Flourish Research
Walnut Creek, California, United States
Jacksonville Center for Clinical Research
Jacksonville, Florida, United States
Suncoast Clinical Research
New Port Richey, Florida, United States
Oviedo Medical Research
Oviedo, Florida, United States
Monroe Biomedical Research
Louisville, Kentucky, United States
Aa Mrc Llc
Flint, Michigan, United States
SKY Integrative Medical Center/SKYCRNG
Ridgeland, Mississippi, United States
Clinical Research Professionals
Chesterfield, Missouri, United States
Mercury Street Medical Group, PLLC
Butte, Montana, United States
Monroe Biomedical Research
Monroe, North Carolina, United States
Accellacare - Wilmington
Wilmington, North Carolina, United States
Velocity Clinical Research, Mt. Auburn
Cincinnati, Ohio, United States
Tribe Clinical Research, LLC
Greenville, South Carolina, United States