Clinical Research Directory

Inclusion Criteria: * confirmed Group A streptococcal (GAS) pharyngitis, defined by a positive rapid antigen detection test * Receiving care at either the University of Texas Pediatrics General Clinic or the Memorial Hermann Emergency Department * Written informed consent obtained from a parent or legal guardian, with assent from the child when developmentally appropriate and required by institutional policy. Exclusion Criteria: * Known allergy or hypersensitivity to penicillin, amoxicillin, or other beta-lactam antibiotics * Severe or complicated illness requiring hospitalization at presentation. * History of acute rheumatic fever, post-streptococcal glomerulonephritis, or other conditions for which prolonged antibiotic therapy is specifically indicated. * Immunocompromised state, including but not limited to: Active malignancy receiving chemotherapy, Solid-organ or hematopoietic stem cell transplant, Chronic systemic immunosuppressive therapy * Antibiotic use with activity against Group A Streptococcus within the preceding 7 days. * Inability to take oral medications or anticipated inability to complete outpatient therapy.