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Effects of Excitatory and Inhibitory LIFUS of GPi in Parkinsonian Patients Without DBS
Sponsor: University Health Network, Toronto
Summary
Low intensity focused ultrasound (LIFUS) is a novel non-invasive brain stimulation (NIBS) technique that permits stimulation with high spatial focality and can reach greater depth compared other methods. This study will look at the effects of two different LIFUS stimulations on task performance in patients with Parkinson's disease. The effects of real stimulation will also be compared to sham stimulation. The evaluations will include behavioral tasks on the computer, the Unified Parkinson's Disease Rating Scale (UPDRS) motor scoring, and finger accelerometry recordings. These will be done before the LIFUS simulations and repeated after. This is to evaluate the different mechanisms and efficacy of these stimulations on deep brain areas.
Key Details
Gender
All
Age Range
18 Years - 90 Years
Study Type
INTERVENTIONAL
Enrollment
15
Start Date
2024-02-14
Completion Date
2028-12
Last Updated
2026-09-29
Healthy Volunteers
No
Conditions
Interventions
LIFUS: Active 5 Hz Theta Burst
LIFUS 5 Hz theta burst bilaterally on the GPi
LIFUS: Active 10 Hz
LIFUS 10 Hz bilaterally on the GPi
LIFUS: Sham
Sham: LIFUS theta burst to occipital lobe
Locations (1)
Toronto Western Hospital
Toronto, Ontario, Canada